The discovery of novel antivirals for the treatment of mpox: is drug repurposing the answer?Review Published on 2023-05-012023-06-10 Journal: Expert opinion on drug discovery [Category] 원숭이두창, [키워드] Drug repurposing Molecular dynamics simulation Mpox virus MPXV structural bioinformatics. [DOI] 10.1080/17460441.2023.2199980 PMC 바로가기 [Article Type] Review
Combining computational and experimental evidence on the activity of antimalarial drugs on papain-like protease of SARS-CoV-2: A repurposing studyArticle Published on 2023-04-012023-07-10 Journal: Chemical biology & drug design [Category] COVID19(2023년), [키워드] Antimalarial drugs Drug repurposing papain-like protease. PL-pro SARS-CoV-2 [DOI] 10.1111/cbdd.14187 PMC 바로가기
Repurposing of the antibiotic nitroxoline for the treatment of mpoxArticle Published on 2023-03-012023-06-10 Journal: Journal of medical virology [Category] 원숭이두창, [키워드] antiviral drugs antiviral therapy chelator Drug repurposing Monkeypox orthopoxvirus poxvirus. [DOI] 10.1002/jmv.28652 PMC 바로가기
Monkeypox and drug repurposing: seven potential antivirals to combat the viral diseaseArticle Published on 2023-02-222023-06-10 Journal: Reviews on environmental health [Category] 원숭이두창, [키워드] antivirals brincidofovir Drug repurposing Monkey Pox mpox orthopoxviruses Pharmaceuticals tecovirimat. [DOI] 10.1515/reveh-2023-0001 PMC 바로가기
Discovery of adapalene and dihydrotachysterol as antiviral agents for the Omicron variant of SARS-CoV-2 through computational drug repurposingArticle Published on 2023-02-012023-07-09 Journal: Molecular diversity [Category] COVID19(2023년), [키워드] Adapalene Drug repurposing Omicron variant SARS-CoV-2 vitamin D. [DOI] 10.1007/s11030-022-10440-6 PMC 바로가기
Methotrexate inhibition of SARS-CoV-2 entry, infection and inflammation revealed by bioinformatics approach and a hamster modelArticle Published on 2022-12-212023-07-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), [키워드] Drug repurposing Inflammation methotrexate multi-target drugs. SARS-CoV-2 [DOI] 10.3389/fimmu.2022.1080897 PMC 바로가기
3D Ex vivo tissue platforms to investigate the early phases of influenza a virus- and SARS-CoV-2-induced respiratory diseasesArticle Published on 2022-12-012022-11-15 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 신약개발, 진단, 치료제, [키워드] animal model animal models Antiviral Cell Cell culture comparable consequence Drug repurposing drug target early phase Ex vivo ex vivo infection Ex vivo infection model Health Host human lung IAV in vitro Infection Inflammatory cytokine Influenza influenza A virus Influenza virus Innate immunity innate immunity. interferon interferon response Intervention introduced lung tissue morbidity and mortality murine outbreak pathophysiological pharmacological platform Respiratory disease respiratory viruses responses SARS-CoV-2 therapy tissue Treatment viral infection viral life cycle viral replication virus virus while [DOI] 10.1080/22221751.2022.2117101 PMC 바로가기
Genomic variants-driven drug repurposing for tuberculosis by utilizing the established bioinformatic-based approachShort communication Published on 2022-12-012022-10-05 Journal: Biochemistry and Biophysics Reports [Category] 신약개발, [키워드] annotations applied approach bioinformatics biological process CCR5 CD44 cellular component contribute CXCR4 demonstrated deregulation disease disease-associated drug Drug discovery Drug repurposing drug target evaluated Evidence facilitate functional functional annotation Genes genomic genomic variant genomic variants GWAS HLA-B identify implementation in-silico indication involved KEGG Missense mutation molecular overlapped Pathogenesis Pathway analysis provided risk SELP suggested target Treatment Tuberculosis variant [DOI] 10.1016/j.bbrep.2022.101334 [Article Type] Short communication
Repurposing antiviral drugs against the human monkeypox virus DNA-dependent RNA polymerase; in silico perspectiveComment Published on 2022-12-012023-07-10 Journal: The Journal of Infection [Category] COVID19(2023년), [키워드] DdRp Drug repurposing homology modeling Human monkeypox virus (HMV) molecular dynamics simulation. [DOI] 10.1016/j.jinf.2022.09.002 PMC 바로가기 [Article Type] Comment
Computational Repurposing of Mitoxantrone-Related Structures against Monkeypox Virus: A Molecular Docking and 3D Pharmacophore StudyArticle Published on 2022-11-182023-06-09 Journal: International Journal of Molecular Sciences [Category] 원숭이두창, [키워드] Drug repurposing Epidemic in silico mitoxantrone molecular docking Monkeypox pharmacophore poxviruses Zoonotic. [DOI] 10.3390/ijms232214287 PMC 바로가기